Scavenger Receptor Cysteine-Rich Type 1 Protein M130 (CD163) Antibody

Este producto es parte de CD163 - CD163 molecule
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273€ (40 µl)

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935106861
info@markelab.com
name
Scavenger Receptor Cysteine-Rich Type 1 Protein M130 (CD163) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx227086
tested applications
IHC

Description

Scavenger Receptor Cysteine-Rich Type 1 Protein M130 (CD163) Antibody is a Rabbit Monoclonal antibody for the detection of CD163.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Scavenger Receptor Cysteine-Rich Type 1 Protein M130 (CD163)
Host
Rabbit
Reactivity
Human
Recommended Dilution
IHC-P: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG
Clone ID
B586
Purification
Purified from rabbit antiserum by proprietary techniques.
Size 1
40 µl
Size 2
100 µl
Size 3
200 µl
Size 4
500 µl
Size 5
1 ml
Form
Liquid
Tested Applications
IHC
Buffer
20 mM Tris-HCl, pH 8.0, containing 20 mg/ml BSA and 0.05% NaN3.
Availability
Shipped within 5-10 working days.
Storage
Store at 2-8°C.
Dry Ice
No
UniProt ID
Q86VB7
Alias
Scavenger receptor cysteine-rich type 1 protein M130,M130,MM130,SCARI1,Hemoglobin scavenger receptor
Background
Antibody anti-CD163
Status
RUO

Descripción

CD163, also known as the hemoglobin scavenger receptor, is a transmembrane glycoprotein expressed primarily on the surface of monocytes and macrophages. Encoded by the CD163 gene on chromosome 12 in humans, CD163 functions as a receptor for the haptoglobin-hemoglobin (Hp-Hb) complex. It is critical in scavenging free hemoglobin (Hb) released during red blood cell breakdown, thus protecting tissues from oxidative damage and inflammation due to free hemoglobin. Additionally, CD163 is part of the cysteine-rich scavenger receptor family and plays an important role in immune modulation, inflammation resolution, and tissue remodeling. Through its function as an anti-inflammatory receptor, CD163 contributes to the regulation of immune responses, often acting as a “sensor” for inflammatory conditions. When inflammation is detected, CD163-expressing cells can trigger responses that help protect tissues, making this molecule an essential component in maintaining immune homeostasis and limiting excessive immune reactions.

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