S1P Receptor EDG1 Cell ELISA Kit
513.5€ (96 tests)
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name
S1P Receptor EDG1 Cell ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx595532
tested applications
ELISA
Description
S1P Receptor EDG1 Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | S1P Receptor EDG1 |
| Reactivity | Human, Mouse, Rat |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. The validity for this kit is at least 6 months |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P21453 |
| Gene ID | 1901 |
| OMIM | 601974 |
| Alias | S1PR1,CD363,CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,S1P1,endothelial differentiation G protein-coupled receptor 1 |
| Background | Elisa kits for S1PR1 |
| Status | RUO |
| Note | Validity: 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
S1PR1 is a G protein-coupled receptor that binds sphingosine-1-phosphate (S1P), a bioactive lipid involved in immune regulation, vascular development, and cellular migration. S1PR1 is widely expressed in endothelial cells, lymphocytes, and smooth muscle cells, where it regulates vascular barrier integrity, immune cell trafficking, and angiogenesis. Activation of S1PR1 by S1P triggers signaling pathways involving Gi proteins, leading to activation of PI3K/Akt, MAPK, and Rac, which regulate cell survival, proliferation, and cytoskeletal dynamics. In the immune system, S1PR1 is critical for lymphocyte egress from lymphoid tissues into circulation, making it a key target for immunosuppressive therapies, such as fingolimod, used in treating multiple sclerosis. In the vasculature, S1PR1 maintains endothelial barrier function and regulates vascular permeability. Dysregulation of S1PR1 signaling is associated with inflammatory diseases, cardiovascular disorders, and cancer, where it promotes tumor angiogenesis and immune evasion. Therapeutically, S1PR1 modulators are being developed for autoimmune diseases, inflammatory conditions, and cancer, highlighting its critical role in immune and vascular homeostasis.
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