S-adenosylmethionine decarboxylase proenzyme (AMD1) Antibody

Este producto es parte de AMD1 - Adenosylmethionine decarboxylase 1
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260€ (50 µl)

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935106861
info@markelab.com
name
S-adenosylmethionine decarboxylase proenzyme (AMD1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx242193
tested applications
ELISA, WB, IHC

Description

AMD1 Antibody is a Rabbit Polyclonal against AMD1.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Primary Antibodies
Immunogen Target
S-adenosylmethionine decarboxylase proenzyme (AMD1)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
ELISA: 1/2000 - 1/5000, WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Antigen Affinity Chromatography.
Size 1
50 µl
Size 2
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IHC
Buffer
PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P17707
Gene ID
262
Alias
AMD,SAMDC,ADOMETDC
Background
Antibody anti-AMD1
Status
RUO

Descripción

Adenosylmethionine Decarboxylase 1 (AMD1) is a key regulatory enzyme in polyamine biosynthesis, catalyzing the decarboxylation of S-adenosylmethionine (SAM) to form S-adenosylmethioninamine (dcSAM). This reaction provides the aminopropyl group for the synthesis of polyamines such as spermidine and spermine, which are essential for cell proliferation, differentiation, and DNA stabilization. AMD1 activity is tightly regulated at multiple levels, including transcription, translation, and post-translational modifications, to meet cellular demands for polyamine production. Dysregulation of AMD1 has been linked to various pathological conditions, including cancer, where increased polyamine synthesis supports tumor growth and survival. Inhibiting AMD1 is being explored as a potential therapeutic strategy for cancer treatment, targeting the overactive polyamine biosynthesis pathway to suppress cell proliferation. AMD1 also plays a role in cellular responses to oxidative stress and metabolic regulation, making it an important enzyme in maintaining cellular homeostasis.

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