Ryanodine Receptor 1, Skeletal (RYR1) Antibody
169€ (20 µg)
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935106861
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name
Ryanodine Receptor 1, Skeletal (RYR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx110194
tested applications
ELISA, IF/ICC
Description
RYR1 is a calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of t-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca2+ leaking into the cytoplasm. RYR1 can also mediate the release of Ca2+ from intracellular stores in neurons, and may thereby promote prolonged Ca2+ signaling in the brain. It is required for normal embryonic development of muscle fibers, skeletal muscle, normal heart morphogenesis, skin development and ossification.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Ryanodine Receptor 1, Skeletal (RYR1) Immunogen: Recombinant human Ryanodine receptor 1 protein (1-534 AA). |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21817 |
| Gene ID | 6261 |
| NCBI Accession | NP_000531.2, NM_000540.2 |
| OMIM | 117000 |
| Alias | RYR-1,RyR1,RYDR |
| Background | Antibody anti-RYR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
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