Rapamycin-Insensitive Companion of mTOR (RICTOR) Antibody (PE)
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Description
RICTOR Antibody (PE) is a Rabbit Polyclonal Antibody against RICTOR.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rapamycin-Insensitive Companion of mTOR (RICTOR) |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Purification | Peptide Affinity Purified |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6R327 |
| Gene ID | 253260 |
| NCBI Accession | NP_001272368.1 |
| OMIM | 609022 |
| Background | Antibody anti-RICTOR |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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RICTOR antibody
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.
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Rapamycin-Insensitive Companion of mTOR (RICTOR) Antibody
RICTOR Antibody is a Rabbit Polyclonal Antibody against RICTOR.
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