Roundabout Homolog 4 (ROBO4) Antibody
377€ (100 µg)
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Name
Roundabout Homolog 4 (ROBO4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx240219
Tested Applications
ELISA, WB, IHC
Description
Roundabout Homolog 4 (ROBO4) Antibody is a Rabbit Polyclonal antibody for the detection of ROBO4.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Roundabout Homolog 4 (ROBO4) Immunogen: roundabout homolog 4, magic roundabout(Drosophila) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 110 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WZ75 |
| Gene ID | 54538 |
| OMIM | 607528 |
| Alias | MRB,AOVD3,ECSM4,Magic roundabout,Roundabout homolog 4 |
| Background | Antibody anti-ROBO4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ROBO4 (Roundabout Guidance Receptor 4) diverges functionally from other ROBO family members by playing a significant role in vascular biology rather than neural development. It is predominantly expressed in endothelial cells and contributes to maintaining vascular integrity by regulating endothelial cell migration, adhesion, and barrier function. ROBO4 interacts with Slit ligands to inhibit pathological angiogenesis and vascular permeability, which is crucial in conditions like inflammation and cancer. Dysregulation of ROBO4 has been implicated in vascular-related disorders, including tumor angiogenesis and chronic inflammatory diseases, underscoring its potential as a therapeutic target in vascular dysfunction and related pathologies.
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