Roundabout Homolog 4 (ROBO4) Antibody
169€ (20 µl)
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935106861
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name
Roundabout Homolog 4 (ROBO4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx321166
tested applications
ELISA, IHC
Description
ROBO4 Antibody is a Rabbit Polyclonal against ROBO4.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Roundabout Homolog 4 (ROBO4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WZ75 |
| Gene ID | 54538 |
| NCBI Accession | NP_001288017.1, NM_001301088.1, NP_061928.4, NM_019055.5 |
| OMIM | 607528 |
| Alias | MRB,AOVD3,ECSM4,Magic roundabout,Roundabout homolog 4 |
| Background | Antibody anti-ROBO4 |
| Status | RUO |
Descripción
ROBO4 (Roundabout Guidance Receptor 4) diverges functionally from other ROBO family members by playing a significant role in vascular biology rather than neural development. It is predominantly expressed in endothelial cells and contributes to maintaining vascular integrity by regulating endothelial cell migration, adhesion, and barrier function. ROBO4 interacts with Slit ligands to inhibit pathological angiogenesis and vascular permeability, which is crucial in conditions like inflammation and cancer. Dysregulation of ROBO4 has been implicated in vascular-related disorders, including tumor angiogenesis and chronic inflammatory diseases, underscoring its potential as a therapeutic target in vascular dysfunction and related pathologies.
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