ROBO4-Specific Antibody

Este producto es parte de ROBO - roundabout guidance receptor
Product Graph
364€ (100 µg)

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935106861
info@markelab.com
name
ROBO4-Specific Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx237375
tested applications
ELISA, WB

Description

ROBO4-Specific Antibody is a Rabbit Polyclonal against ROBO4-Specific.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
ROBO4-Specific
Host
Rabbit
Reactivity
Human, Mouse
Recommended Dilution
WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q8WZ75
Gene ID
54538
Alias
MRB,AOVD3,ECSM4,Magic roundabout,Roundabout homolog 4
Background
Antibody anti-ROBO4
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

ROBO4 (Roundabout Guidance Receptor 4) diverges functionally from other ROBO family members by playing a significant role in vascular biology rather than neural development. It is predominantly expressed in endothelial cells and contributes to maintaining vascular integrity by regulating endothelial cell migration, adhesion, and barrier function. ROBO4 interacts with Slit ligands to inhibit pathological angiogenesis and vascular permeability, which is crucial in conditions like inflammation and cancer. Dysregulation of ROBO4 has been implicated in vascular-related disorders, including tumor angiogenesis and chronic inflammatory diseases, underscoring its potential as a therapeutic target in vascular dysfunction and related pathologies.

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