Rho GDP-Dissociation Inhibitor 1 (ARHGDIA) Antibody
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Description
Rho GDP-Dissociation Inhibitor 1 (ARHGDIA) Antibody is a Rabbit polyclonal antibody for the detection of Human Rho GDP-Dissociation Inhibitor 1 (ARHGDIA).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Rho GDP-Dissociation Inhibitor 1 (ARHGDIA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to 2 weeks. For long-term storage, aliquot and store at -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P52565 |
| Gene ID | 396 |
| NCBI Accession | NP_001172006.1 |
| Background | Antibody anti-ARHGDIA |
| Status | RUO |
Descripción
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Rho GDP-Dissociation Inhibitor 1 (ARHGDIA) Antibody
ARHGDIA Antibody is a Rabbit Polyclonal antibody against ARHGDIA. Rho family small GTPases, including Rho, Rac and cdc42, act as molecular switches, regulating processes such as cell migration, adhesion, proliferation and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. A third level of regulation is provided by the stoichiometric binding of Rho GDP dissociation inhibitor (RhoGDI). RhoGDI affects Rho activity by inhibiting nucleotide exchange and membrane association, regulating activity and localization (Reviewed in 1, 2). The inhibitory and shuttling functions of RhoGDI have been uncoupled using mutant forms of RhoGDI (3). Phosphorylation of GDIs and/or GTPases can modulate their affinity for each other and, therefore, GTPase mediated signaling. PAK1 phosphorylation of RhoGDI at serines 101 and 174 causes release and activation of Rac1, but not RhoA (4).
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