Retinoic Acid Receptor beta DNA-Binding ELISA Kit
559€ (96 tests)
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Name
Retinoic Acid Receptor beta DNA-Binding ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx596553
Tested Applications
ELISA
Description
Retinoic Acid Receptor beta DNA-Binding ELISA Kit is an ELISA Kit against Retinoic Acid Receptor beta.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Retinoic Acid Receptor beta |
| Reactivity | Human, Mouse |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P10826 |
| Gene ID | 5915 |
| OMIM | 180220 |
| Alias | RAR,NR1B1,RARalpha,Nuclear receptor subfamily 1 group B member 1 |
| Background | Elisa Kits for: RARA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
Retinoic acid receptor alpha (RARA) is a nuclear receptor that mediates the biological effects of retinoic acid, an active metabolite of vitamin A, by regulating gene expression RARA forms a heterodimer with retinoid X receptor (RXR) and binds to retinoic acid response elements (RAREs) in the promoter regions of target genes, controlling processes such as cell growth, differentiation, and apoptosis It plays a pivotal role in embryonic development, immune function, and skin health, and its activity is crucial for maintaining cellular homeostasis During development, RARA influences the differentiation of neural, hematopoietic, and epithelial cells, while in adults, it regulates processes like cell renewal and immune responses Dysregulation of RARA expression or function is linked to several diseases, including cancer, where mutations or overexpression of RARA can lead to the inappropriate activation of genes involved in tumor growth and metastasis It is also implicated in disorders such as acute promyelocytic leukemia (APL), where fusion of RARA with other genes causes abnormal gene expression that promotes leukemia cell proliferation
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