Retinoic Acid Receptor Alpha (RARA) Antibody

Descripción

RARA Antibody is a Rabbit Polyclonal antibody against RARA. Retinoids (vitamin A and its active retinoic acid derivatives) are non-steroid hormones that regulate cell prolifeRation, differentiation and apoptosisRetinoic acid receptors (RARalpha, -beta and -gamma) and retinoid X receptors (RXRalpha, -beta and -gamma) are nuclear receptors that function as RAR-RXR heterodimers or RXR homodimersIn response to retinoid binding, these dimers control gene expression by binding to specific retinoic acid response elements, by recruiting cofactors and the transcriptional machinery, and by indirectly regulating chromatin structureFinally, ligand binding and phosphorylation of RARalpha by JNK at Thr181, Ser445 and Ser461 controls the stability of RAR-RXR through the ubiquitin-proteasome pathwayAt least four distinct genetic lesions affect RARalpha and result in acute promyelocytic leukemia (APL)The t(15;17) translocation that results in the PML-RARalpha fusion protein is responsible for more than 99% of APL cases, and the fusion protein inhibits PML-dependent apoptotic pathways in a dominant negative fashionIn addition PML-RARalpha inhibits transcription of retinoic acid target genes by recruiting co-repressors, attenuating myeloid differentiation.