Retinoic Acid Receptor Alpha (RARa) Antibody
273€ (100 µl)
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Name
Retinoic Acid Receptor Alpha (RARa) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx102933
Description
Polyclonal Antibody to Retinoic Acid Receptor Alpha (RARa).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Retinoic Acid Receptor Alpha (RARa) Immunogen: RARa (Val237-Pro459) |
| Host | Rabbit |
| Reactivity | Rat |
| Recommended Dilution | WB (Predicted): 0.01-2 µg/ml, IHC (Predicted): 5-20 µg/ml, IF/ICC (Predicted): 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q499N1 |
| Alias | RAR,NR1B1,RARalpha,Nuclear receptor subfamily 1 group B member 1 |
| Background | Antibody anti-RARA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Retinoic acid receptor alpha (RARA) is a nuclear receptor that mediates the biological effects of retinoic acid, an active metabolite of vitamin A, by regulating gene expression RARA forms a heterodimer with retinoid X receptor (RXR) and binds to retinoic acid response elements (RAREs) in the promoter regions of target genes, controlling processes such as cell growth, differentiation, and apoptosis It plays a pivotal role in embryonic development, immune function, and skin health, and its activity is crucial for maintaining cellular homeostasis During development, RARA influences the differentiation of neural, hematopoietic, and epithelial cells, while in adults, it regulates processes like cell renewal and immune responses Dysregulation of RARA expression or function is linked to several diseases, including cancer, where mutations or overexpression of RARA can lead to the inappropriate activation of genes involved in tumor growth and metastasis It is also implicated in disorders such as acute promyelocytic leukemia (APL), where fusion of RARA with other genes causes abnormal gene expression that promotes leukemia cell proliferation
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