Retinal Dehydrogenase 1 (ALDH1A1) Antibody
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Description
ALDH1A1 Antibody is a Goat Polyclonal antibody against ALDH1A1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Retinal Dehydrogenase 1 (ALDH1A1) |
| Host | Goat |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 216, 11668, 24188 |
| NCBI Accession | NP_000680.2 |
| Alias | 3-deoxyglucosone dehydrogenase 1,ALDH-E1,ALHDII |
| Background | Antibody anti-ALDH1A1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
ALDH1A1 is a cytosolic enzyme primarily responsible for catalyzing the oxidation of retinaldehyde to retinoic acid, a biologically active metabolite of vitamin A that regulates gene expression via retinoic acid receptors (RARs). ALDH1A1 plays a pivotal role in embryonic development, cell differentiation, and tissue regeneration, particularly in the eyes, liver, and hematopoietic systems. It is a well-known marker for cancer stem cells (CSCs) in various tumors, including breast, lung, and prostate cancers, where its overexpression contributes to chemoresistance, metastasis, and tumor initiation. ALDH1A1 is also involved in detoxifying reactive aldehydes, such as 4-hydroxynonenal (4-HNE), providing protection against oxidative stress. Its role in maintaining stem cell populations and redox homeostasis highlights ALDH1A1 as a therapeutic target in oncology. Additionally, ALDH1A1 is implicated in alcohol metabolism and the development of alcohol-related liver diseases.
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