Recombinant Human UCHL1
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935106861
info@markelab.com
name
Recombinant Human UCHL1
category
Proteins and Peptides
provider
FineTest
reference
P1246
tested applications
Western Blot, ELISA
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Availability | 7 days |
| Background | Proteins UCHL1 |
| Buffer | Reconstitute with Sterile distilled water |
| Category | Proteins and Peptides |
| Expression | Recombinant |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
| Host | E.Coli |
| Immunogen Target | 1-220 |
| Name | Recombinant Human UCHL1 |
| Note | This product is for research use only. |
| Observed MW | 26.4 KDa |
| Origin | Human |
| Provider | FineTest |
| Purification | His tag |
| Purity | Greater than 95% by SDS-PAGE gel analyses |
| Reference | P1246 |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Status | RUO |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| Tested Applications | Western Blot, ELISA |
| UniProt ID | P09936 |
Background en español
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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