Recombinant Human ROBO4
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935106861
info@markelab.com
name
Recombinant Human ROBO4
category
Proteins and Peptides
provider
FineTest
reference
P0792
tested applications
Western Blot, ELISA
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 28-235 |
| Host | E.Coli |
| Origin | Human |
| Observed MW | 24 KDa |
| Expression | Recombinant |
| Purity | Greater than 95% by SDS-PAGE gel analyses |
| Purification | His tag |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4 |
| Tested Applications | Western Blot, ELISA |
| Buffer | Reconstitute with Sterile distilled water |
| Availability | 7 days |
| Storage | -20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution |
| UniProt ID | Q8WZ75 |
| Alias | MRB,AOVD3,ECSM4,Magic roundabout,Roundabout homolog 4 |
| Background | Proteins ROBO4 |
| Status | RUO |
| Note | This product is for research use only. |
ROBO4 (Roundabout Guidance Receptor 4) diverges functionally from other ROBO family members by playing a significant role in vascular biology rather than neural development. It is predominantly expressed in endothelial cells and contributes to maintaining vascular integrity by regulating endothelial cell migration, adhesion, and barrier function. ROBO4 interacts with Slit ligands to inhibit pathological angiogenesis and vascular permeability, which is crucial in conditions like inflammation and cancer. Dysregulation of ROBO4 has been implicated in vascular-related disorders, including tumor angiogenesis and chronic inflammatory diseases, underscoring its potential as a therapeutic target in vascular dysfunction and related pathologies.
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