Recombinant Human MYBPC3

Background

MYBPC3 is a crucial component of the sarcomere in cardiac muscles, where it regulates cardiac contractility and stabilizes the structural framework of the thick filament. Through its interactions with myosin and actin, it modulates the force and efficiency of cardiac muscle contraction, playing a central role in maintaining the heart’s mechanical function. Mutations in MYBPC3 are a common genetic cause of hypertrophic cardiomyopathy (HCM), a condition characterized by the abnormal thickening of the heart muscle that can lead to heart failure and arrhythmias. These mutations often result in impaired sarcomere function and contribute to maladaptive cardiac remodeling. Research on MYBPC3 focuses on its role in cardiomyopathy pathogenesis and its potential as a therapeutic target for improving heart function in affected individuals.