MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Stromelysin-1, also recognized as matrix metalloproteinase-3 (MMP-3), is an enzyme encoded by the MMP3 gene in humans. Aliases are: CHDS6, MMP-3, SL-1, STMY, STMY1, and STR1.This enzyme plays a significant role in the degradation of fibronectin, laminin, as well as collagens III, IV, IX, and X, along with cartilage proteoglycans. MMP-3 is involved in various biological processes such as wound repair, the progression of atherosclerosis, and the initiation of tumors.
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La estromelisina-1, también reconocida como metaloproteinasa de matriz-3 (MMP-3), es una enzima codificada por el gen MMP3 en humanos. Los alias son: CHDS6, MMP-3, SL-1, STMY, STMY1 y STR1. Esta enzima juega un papel importante en la degradación de la fibronectina, la laminina, así como los colágenos III, IV, IX y X, junto con el cartílago. proteoglicanos. MMP-3 participa en diversos procesos biológicos, como la reparación de heridas, la progresión de la aterosclerosis y la iniciación de tumores.
Proteins and Peptides
Human
E.Coli
100-273
E.Coli
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
Western Blot,ELISA
50μg
200μg
1mg
19 kDa
Recombinant
Greater than 95% by SDS-PAGE gel analyses
His tag
Reconstitute with Sterile distilled water
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
MMP3
3-4 weeks
CHDS6, Matrix metalloproteinase 3, Matrix metalloproteinase 3 preproprotein, Matrix metalloproteinase-3, MGC126102, MGC126103, MGC126104, MMP 3, MMP-3, MMP3, MMP3_HUMAN, Proteoglycanase, SL-1, SL1, STMY, STMY1, STR1, Stromelisin 1, Stromelysin 1, Stromelysin 1 progelatinase, Stromelysin-1, Transin 1, Transin-1
This product is for research use only.
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