MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Interstitial collagenase, also recognized as matrix metalloproteinase-1 (MMP-1), is an enzyme encoded by the MMP1 gene in humans. This enzyme, when secreted, serves to degrade interstitial collagens, including types I, II, and III. It is also known by aliases such as CLG and CLGN
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La colagenasa intersticial, también reconocida como metaloproteinasa de matriz-1 (MMP-1), es una enzima codificada por el gen MMP1 en humanos. Esta enzima, cuando se secreta, sirve para degradar los colágenos intersticiales, incluidos los tipos I, II y III. También se le conoce con alias como CLG y CLGN
Proteins and Peptides
Human
HEK 293 cells
20-469
HEK 293 cells
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose and 0.06% proclin, pH7.4
Western Blot, ELISA
50μg
200μg
1mg
50-55 kDa
Recombinant
Greater than 95% by SDS-PAGE gel analyses
C-terminal His Tag
Centrifuge the vial at 10,000 rpm for 1 minute, reconstitute at 100 μg/ml in Reconstitute with Sterile distilled water
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
MMP-1
7 days
CLG, CLGN, Fibroblast collagenase, Interstitial collagenase, Matrix metalloproteinase 1, MMP 1, MMP1
This product is for research use only.
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