Recombinant Human EIF2AK3
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Product specifications
| Category | Proteins and Peptides |
| Host | E.Coli |
| Reactivity | Human |
| Assay Data | Centrifuge the vial before opening, reconstitute in sterile distilled water to a concentration of 0.1-1 mg/ml by gently pipetting 2-3 times, don't vortex. |
| Recommended Dilution | ¥ |
| Isotype | ¥ |
| Clone ID | ¥ |
| Observed MW | 38.2 kDa |
| Expression | 963-1116 |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Size 1 | 50μg |
| Size 2 | 200μg |
| Size 3 | 1mg |
| Form | Lyophilized powder |
| Tested Applications | Western Blot, ELISA |
| Buffer | Lyophilized from a 0.2 μm filtered solution in 10 mM Hepes, 500 mM NaCl with 5% trehalose, pH 7.4. |
| Availability | 7 days |
| Storage | The lyophilized protein is stable at -20 °C for up to 1 year. After reconstitution, the protein solution is stable at -20 to -80 °C for 3 months or 1 week at 2 to 8 °C under sterile conditions. For extended storage, it is recommended to further dilute in working aliquots, avoid repeated freeze/thaw cycle. |
| UniProt ID | Q9NZJ5 |
| Alias | DKFZp781H1925, E2AK3_HUMAN, EC 2.7.11.1, Eif2ak3, Eukaryotic translation initiation factor 2 alpha kinase 3, Eukaryotic translation initiation factor 2-alpha kinase 3, Heme regulated EIF2 alpha kinase, HRI, HsPEK, Pancreatic eIF2 alpha kinase, Pancreatic eIF2-alpha kinase |
| Background | Protein EIF2AK3 |
| Status | RUO |
| Note | Tag : N-terminal His-IF2DI Tag |
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Human EIF2AK3 (Eukaryotic translation initiation factor 2-alpha kinase 3) ELISA Kit
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EIF2AK3 antibody
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2(eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response(UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response(UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function.
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