Recombinant Human CD45
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Precio
Precio a consultar
Proteins PTPRC
proveedor
FineTestreference
P1394Tested Applications
Western Blot, ELISAreactivity
status
RUOclonality
Background
PTPRC, also known as CD45, is a receptor-type tyrosine phosphatase primarily expressed in hematopoietic cells. It regulates antigen receptor signaling in lymphocytes by dephosphorylating inhibitory residues on Src family kinases such as Lck and Fyn. Structurally, PTPRC has an extracellular domain, a single transmembrane region, and two cytoplasmic phosphatase domains, with the first being catalytically active. It is critical for T-cell and B-cell activation, development, and immune response regulation. Mutations in PTPRC are linked to severe immunodeficiency disorders, including SCID, and its overexpression is associated with autoimmune diseases and leukemia.
Características del producto
category
Proteins and Peptides
origin
Human
host
E.Coli
immunogen target
915-1306
host
E.Coli
form
Lyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
tested applications
Western Blot, ELISA
size 1
50μg
size 2
200μg
size 3
1mg
observerd MW
45.4 kDa
expression
Recombinant
purity
Greater than 95% by SDS-PAGE gel analyses
purification
His tag
buffer
Reconstitute with Sterile distilled water
storage
-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
or code
PTPRC
availability
7 days
alias
LCA,LY5,B220,CD45,L-CA,T200,CD45R,GP180,IMD105,CD45,Leukocyte common antigen,Receptor-type tyrosine-protein phosphatase C
uniprot id
note
This product is for research use only.
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