Recombinant Human AMACR

Este producto es parte de AMACR - Alpha-methylacyl-CoA racemase
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935106861
info@markelab.com
name
Recombinant Human AMACR
category
Proteins and Peptides
provider
FineTest
reference
P1405
tested applications
Western Blot, ELISA

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Product specifications

CategoryProteins and Peptides
Immunogen Target171-382
HostE.Coli
OriginHuman
Observed MW25.9 kDa
ExpressionRecombinant
PurityGreater than 95% by SDS-PAGE gel analyses
PurificationHis tag
Size 150μg
Size 2200μg
Size 31mg
FormLyophilized from a 0.2um filtered solution in PBS with 5% trehalose, pH7.4
Tested ApplicationsWestern Blot, ELISA
BufferReconstitute with Sterile distilled water
Availability7 days
Storage-20°C for 12 months as lyophilized;2-8°C for 1 month under sterile conditions after reconstitution
UniProt IDQ9UHK6
AliasAMACR
BackgroundProteins AMACR
StatusRUO
NoteThis product is for research use only.

Alpha-Methylacyl-CoA Racemase (AMACR) is a mitochondrial and peroxisomal enzyme that catalyzes the racemization of alpha-methyl-branched fatty acid derivatives and bile acid intermediates, enabling their further metabolism via beta-oxidation. AMACR is critical in lipid metabolism, particularly in the breakdown of dietary branched-chain fatty acids and the processing of bile acids derived from cholesterol. It is highly expressed in tissues with active fatty acid metabolism, such as the liver and kidneys. Dysregulation or mutations in the AMACR gene are associated with metabolic disorders, including adult-onset sensory neuropathy and bile acid metabolism defects. Additionally, AMACR is a well-established biomarker for prostate cancer and other malignancies, as its overexpression is linked to cancer cell metabolism and tumor progression. Targeting AMACR enzymatic activity is being explored as a therapeutic strategy in cancer and metabolic disorders.

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