Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) Antibody

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Description
Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) Antibody is a Rabbit polyclonal antibody for the detection of Human Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q15303 |
| Gene ID | 2066 |
| NCBI Accession | NP_001036064.1 |
| Background | Antibody anti-ERBB4 |
| Status | RUO |
Descripción
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ERBB4 antibody
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
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