Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) Antibody

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Description
Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) Antibody is a Mouse Monoclonal antibody for the detection of Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) in Human samples.
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Product specifications
Category | Primary Antibodies |
Immunogen Target | Receptor Tyrosine-Protein Kinase Erbb-4 (ERBB4) |
Host | Mouse |
Reactivity | Human |
Clonality | Monoclonal |
Conjugation | Unconjugated |
Isotype | IgG2a |
Clone ID | B121 |
Purity | > 95% |
Purification | Purified by Protein A/G affinity chromatography. |
Size 1 | 50 µg |
Size 2 | 100 µg |
Form | Liquid |
Tested Applications | FCM |
Buffer | 0.01 M PBS, pH 7.4. |
Availability | Shipped within 5-12 working days. |
Storage | Store at 4 °C if the entire vial will be used within 1 week. Aliquot and store at -20 °C or -80 °C for long-term storage. Avoid repeated freeze-thaw cycles. |
Dry Ice | No |
UniProt ID | Q15303 |
Gene ID | 2066 |
NCBI Accession | NP_001036064.1 |
Background | Antibody anti-ERBB4 |
Status | RUO |
Note | Concentration: 1 mg/ml - |
Descripción
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ERBB4 antibody
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
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