Receptor tyrosine-protein kinase erbB-2 Phospho-Tyr1221/Y1222 (ERBB2 pY1221/Y1222) Antibody
Pida mas información
935106861
info@markelab.com
Precio
221€ (50 µg)
Antibody anti-ERBB2
proveedor
Abbexareference
abx329715Tested Applications
ELISA, WB, IHC, IPreactivity
Human, Mouse, Ratstatus
RUOclonality
PolyclonalDescripción
ERBB2 (pY1221/Y1222) Antibody is a Rabbit Polyclonal against ERBB2 (pY1221/Y1222).
Background
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human, Mouse, Rat
immunogen target
Receptor tyrosine-protein kinase erbB-2 Phospho-Tyr1221/Y1222 (ERBB2 pY1221/Y1222)
host
Rabbit
isotype
IgG
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, IP
purification
Purified by affinity chromatography.
recommended dilution
ELISA: 1/20000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IP: 2-5 µg. Optimal dilutions/concentrations should be determined by the end user.
buffer
PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
size 1
50 µg
size 2
100 µg
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
ERBB2
dry ice
No
availability
Shipped within 5-10 working days.
alias
Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2
uniprot id
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