Receptor tyrosine-protein kinase erbB-2 Phospho-Tyr1221/Phospho-Tyr1222 (ERBB2 pY1221/pY1222) Antibody

Este producto es parte de ERBB2 - erb-b2 receptor tyrosine kinase 2
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429€ (100 µl)

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935106861
info@markelab.com
name
Receptor tyrosine-protein kinase erbB-2 Phospho-Tyr1221/Phospho-Tyr1222 (ERBB2 pY1221/pY1222) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx332875
tested applications
ELISA, WB, IF/ICC

Description

ERBB2 (pY1221/pY1222) Antibody is a Rabbit Polyclonal against ERBB2 (pY1221/pY1222).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Receptor tyrosine-protein kinase erbB-2 Phospho-Tyr1221/Phospho-Tyr1222 (ERBB2 pY1221/pY1222)
Host
Rabbit
Reactivity
Human
Assay Data
Modification: Phosphorylation // Target Modification: Tyr1221/1222
Recommended Dilution
WB: 1/500 - 1/1000, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified by affinity chromatography.
Size 1
100 µl
Form
Liquid
Tested Applications
ELISA, WB, IF/ICC
Buffer
PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P04626
Gene ID
2064
Alias
Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2
Background
Antibody anti-ERBB2
Status
RUO

Descripción

ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.

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