Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody (APC)
429€ (100 tests)
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935106861
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name
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx140902
tested applications
FCM
Description
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody (APC) is a Mouse Monoclonal against Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) |
| Host | Mouse |
| Reactivity | Human |
| Clonality | Monoclonal |
| Conjugation | APC |
| Isotype | IgG1 |
| Clone ID | O870 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P04626 |
| Gene ID | 2064 |
| Alias | Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2 |
| Background | Antibody anti-ERBB2 |
| Status | RUO |
Descripción
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
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