Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody
2834€ (1 mg)
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935106861
info@markelab.com
name
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx342066
tested applications
SDS-PAGE
Description
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody is a recombinant single domain antibody.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | sdAb |
| Clone ID | T546 |
| Purity | > 90% (SDS-PAGE) |
| Purification | Affinity purified. |
| Size 1 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 1X PBS containing 0.09% Sodium azide. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| Alias | Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2 |
| Background | Antibody anti-ERBB2 |
| Status | RUO |
| Note | Concentration: > 1 mg/ml - |
Descripción
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
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