Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody
351€ (0.1 mg)
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Name
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140893
Tested Applications
IF/ICC, FCM
Description
Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) Antibody is a Mouse Monoclonal against Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Receptor Tyrosine-Protein Kinase ErbB-2 (ERBB2) |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | O870 |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IF/ICC, FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P04626 |
| Gene ID | 2064 |
| Alias | Receptor tyrosine-protein kinase erbB-2,NEU,NGL,HER2,TKR1,CD340,HER-2,VSCN2,MLN 19,MLN-19,c-ERB2,c-ERB-, HER-2/neu; p185(erbB2),Metastatic lymph node gene 19 protein,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface,p185erbB2 receptor HER2 |
| Background | Antibody anti-ERBB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ERBB2, also known as HER2 (human epidermal growth factor receptor 2), is a receptor tyrosine kinase that is part of the ERBB receptor family. This family consists of four closely related receptors: EGFR (ERBB1), HER2 (ERBB2), HER3 (ERBB3), and HER4 (ERBB4). These receptors play crucial roles in cellular signaling pathways regulating cell growth, differentiation, survival, and apoptosis. ERBB2 is particularly significant due to its role in breast cancer and other cancers, where its overexpression or gene amplification is associated with aggressive tumor behavior and poor prognosis. ERBB2 lacks a direct ligand-binding domain but acts as a co-receptor to enhance signaling when paired with other ERBB family members. Its importance in oncology has led to the development of therapies targeting HER2, such as monoclonal antibodies and tyrosine kinase inhibitors.
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