Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody (PE)
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Description
ROR1 Antibody (PE) is a Rabbit Polyclonal Antibody against ROR1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/1000, IHC: 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Purification | Peptide Affinity Purified |
| Size 1 | 100 µg |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01973 |
| Gene ID | 4919 |
| NCBI Accession | NP_001077061.1 |
| Alias | NTRKR1,dJ537F10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,Neurotrophic tyrosine kinase, receptor-related 1 |
| Background | Antibody anti-ROR1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1) is a member of the receptor tyrosine kinase family, playing a pivotal role in embryonic development and cellular signaling. While minimally expressed in normal adult tissues, ROR1 is highly expressed in various cancers, including chronic lymphocytic leukemia and breast cancer, where it contributes to tumor progression, survival, and metastasis. This makes ROR1 a promising therapeutic target in oncology. The receptor participates in Wnt5a-mediated non-canonical Wnt signaling pathways, which regulate cell migration and cytoskeletal dynamics, critical processes during development and pathological states such as cancer. Its restricted expression pattern in normal tissues highlights its potential for targeted cancer therapies.
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