Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody Pair
1261€ (5 × 96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody Pair
Category
Antibody Pairs
Provider
Abbexa
Reference
abx370222
Tested Applications
ELISA
Description
Tumor Necrosis Factor Ligand Superfamily Member 11 (TNFSF11) Antibody Pair for use in Sandwich ELISA assay development. This antibody pair contains: Detection: 50 µg Capture: 200 µg Standard: 2 µg
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Antibody Pairs |
| Immunogen Target | Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) |
| Reactivity | Human |
| Assay Data | Concentration Capture Antibody: 0.5 mg/ml Concentration Biotin-Conjugated Detection Antibody: 0.2 mg/ml Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
| Assay Type | Sandwich |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Biotin |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard form: Lyophilized Capture Ab: Liquid Detection Ab: Liquid |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Shipped within 5-20 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O14788 |
| Gene ID | 8600 |
| Alias | Tumor necrosis factor ligand superfamily member 11,ODF,OPGL,sOdf,CD254,OPTB2,RANKL,TNLG6B,TRANCE,hRANKL2,Osteoclast differentiation factor,Osteoprotegerin ligand,Receptor activator of nuclear factor kappa-B ligand, |
| Background | Antibody pair for TNFSF11 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
TNFSF11, also known as RANKL (Receptor Activator of Nuclear Factor Kappa-Β Ligand), is a member of the tumor necrosis factor (TNF) superfamily. This protein is critical for bone metabolism, immune system regulation, and lymphoid tissue development. RANKL is primarily expressed on osteoblasts, T cells, and stromal cells, playing a major role in osteoclast differentiation and activation by binding to its receptor, RANK (Receptor Activator of Nuclear Factor Kappa-Β). Through the interaction between RANK and RANKL, this signaling pathway facilitates bone remodeling by controlling osteoclast-mediated bone resorption. RANKL is also vital in immune responses and is implicated in the formation of lymph nodes and mammary gland development. The physiological significance of TNFSF11 is underscored by its role in balancing bone formation and resorption. Disruptions in RANKL signaling can lead to metabolic bone disorders such as osteoporosis and osteopetrosis. RANKL is also an area of interest in cancer research, particularly in understanding bone metastasis in certain cancers, as well as autoimmune diseases where its role in immune regulation may contribute to chronic inflammation.
Productos relacionados
Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody
TNFSF11 Antibody is a Rabbit Polyclonal antibody against TNFSF11. This gene encodes a member of the tumor necrosis facto…
Ver producto
Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody
Rabbit polyclonal antibody against TNFSF11 protein. Immunogen region is Internal.…
Ver producto
Tumor Necrosis Factor Ligand Superfamily Member 11 / RANKL (TNFSF11) Antibody
Rabbit Polyclonal against the TNFSF11 protein.…
Ver producto