Rat Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) ELISA Kit

Este producto es parte de FLT4 -  fms related receptor tyrosine kinase 4
Rat Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

618.75€ (96 tests)

Elisa Kits FLT4

proveedor

Abbexa

reference

abx156225

Tested Applications

ELISA

reactivity

Rat

status

RUO

clonality

Descripción

Rat Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat VEGFR3 concentrations in serum, plasma, tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Vascular Endothelial Growth Factor Receptor 3 (VEGFR3)No significant cross-reactivity or interference between Vascular Endothelial Growth Factor Receptor 3 (VEGFR3) and analogues was observed.


Background

Fms related receptor tyrosine kinase 4 (FLT4) FLT4, also known as vascular endothelial growth factor receptor 3 (VEGFR3), is a receptor tyrosine kinase critical for the regulation of lymphangiogenesis, the formation of lymphatic vessels. Structurally, FLT4 comprises an extracellular domain with seven immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FLT4 binds VEGF-C and VEGF-D ligands, leading to receptor dimerization and activation of downstream signaling pathways, including the MAPK and PI3K-AKT cascades. These pathways are essential for lymphatic endothelial cell proliferation, migration, and survival. FLT4 is predominantly expressed in lymphatic endothelial cells, where it plays a pivotal role in maintaining lymphatic vessel integrity and fluid homeostasis. Dysregulation of FLT4 has been linked to lymphedema, a condition characterized by lymphatic fluid accumulation, and its overexpression has been implicated in cancer progression, where it promotes tumor lymphangiogenesis and metastasis. FLT4 is a promising therapeutic target for modulating lymphatic function in both pathological and developmental contexts.

Características del producto

category

ELISA Kits


immunogen target

Vascular Endothelial Growth Factor Receptor 3 / VEGFR3 (FLT4)


reactivity

Rat


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.07 ng/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Tissue homogenates,Other biological fluids


size 1

96 tests


size 2

5 × 96 tests


size 3

10 × 96 tests


alias

PCL,CHTD7,FLT-4,FLT41,LMPH1A,LMPHM1,VEGFR3,VEGFR-3,Tyrosine-protein kinase receptor FLT4,Fms-like tyrosine kinase 4,Vascular endothelial growth factor receptor 3


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

FLT4


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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