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Rat Vascular Cell Adhesion Molecule 1 (VCAM1) ELISA Kit
proveedor
Abbexareference
abx256090Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Vascular Cell Adhesion Molecule 1 / CD106 (VCAM1) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
Vascular cell adhesion protein 1, also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106), is a human protein encoded by the VCAM1 gene. VCAM-1 plays a critical role in interacting with the integrin very late antigen-4 (VLA4).VCAM-1 is responsible for facilitating the adhesion of various immune cells, including lymphocytes, monocytes, eosinophils, and basophils, to the endothelial blood vessel. Additionally, it plays a vital role in signal transduction between leukocytes and endothelial cells, and it has been implicated in the development of conditions such as atherosclerosis and rheumatoid arthritis. Ectodomain release of VCAM-1 is observed in various situations and is often mediated by enzymes like matrix metalloproteinases (MMPs) and ADAMs (A Disintegrin and Metalloproteinase). This release can be triggered by external factors such as calcium ionophores, cytokines, and growth factors. VCAM-1 is also known by the alias CD106
Background
La proteína de adhesión de células vasculares 1, también conocida como molécula de adhesión de células vasculares 1 (VCAM-1) o Cluster de diferenciación 106 (CD106), es una proteína humana codificada por el gen VCAM1. VCAM-1 desempeña un papel fundamental en la interacción de la integrina (VLA4 Very late Antigen-4). VCAM-1 es responsable de facilitar la adhesión de varias células inmunitarias, incluidos linfocitos, monocitos, eosinófilos y basófilos, al vaso sanguíneo endotelial. . Además, desempeña un papel vital en la transducción de señales entre leucocitos y células endoteliales, y se ha implicado en el desarrollo de enfermedades como la aterosclerosis y la artritis reumatoide. La liberación de ectodominio de VCAM-1 se observa en diversas situaciones y, a menudo, está mediada por enzimas como las metaloproteinasas de matriz (MMP) y ADAM (desintegrina A y metaloproteinasa). Esta liberación puede ser provocada por factores externos como ionóforos de calcio, citocinas y factores de crecimiento. VCAM-1 también es conocido con el alias CD106
Características del producto
category
ELISA Kits
immunogen target
Vascular Cell Adhesion Molecule 1 (VCAM1)
reactivity
Rat
test range
12.5 pg/ml - 800 pg/ml
sensitivity
7.5 pg/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
V-CAM 1,VCAM-1,INCAM-100,CD106
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
VCAM1
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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