Rat Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) ELISA Kit
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Description
Rat Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Transient receptor potential cation channel subfamily V member 4 concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Transient Receptor Potential Cation Channel Subfamily V Member 4 (TRPV4) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9ERZ8 |
| Gene ID | 66026 |
| Background | Elisa kits for TRPV4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
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Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification(PubMed:18826956, PubMed:18695040). Also activated by heat, low pH, citrate and phorbol esters(PubMed:18826956, PubMed:18695040). Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism(PubMed:12724311, PubMed:18826956). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers(By similarity). Acts as a regulator of intracellular Ca(2+) in synoviocytes(PubMed:19759329). Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8(PubMed:19759329). Together with PKD2, forms mechano-and thermosensitive channels in cilium(PubMed:18695040). Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes(By similarity). Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes(By similarity). Together with AQP5, controls regulatory volume decrease in salivary epithelial cells(By similarity).
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