Rat Transforming Growth Factor Beta 1 (TGFB1) Protein (Active)

Este producto es parte de TGFB1 - Transforming Growth Factor Beta 1
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273€ (5 µg)

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935106861
info@markelab.com
name
Rat Transforming Growth Factor Beta 1 (TGFB1) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx693696
tested applications
SDS-PAGE

Description

Rat TGF beta 1 Protein is a recombinant protein from Rat produced in HEK293 Cells. A DNA sequence encoding the rat TGFB1 (Ala279-Ser390) was expressed. Rat and Mouse mature TGFB1 sequences are identical.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
TGF beta 1
Host
HEK293 cells
Origin
Rat
Observed MW
Molecular Weight: 12.8 kDa
Sequence Fragment: Ala279-Ser390
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
5 µg
Size 2
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
CED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta
Background
Protein TGFB1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.

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