Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit

Este producto es parte de TGFB1 - Transforming Growth Factor Beta 1
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546€ (96 tests)

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935106861
info@markelab.com
name
Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx256046
tested applications
ELISA

Description

Transforming Growth Factor Beta 1 (TGFB1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Transforming Growth Factor beta 1 concentrations in serum, plasma, cell culture supernatants and other biological fluids.

Documents del producto

Instrucciones
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Data sheet
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Product specifications

CategoryELISA Kits
Immunogen TargetTransforming Growth Factor Beta 1 (TGFB1)
ReactivityHuman, Mouse, Rat, Pig, Rabbit, Dog
Detection MethodColorimetric
Assay DataQuantitative
Assay TypeSandwich
Test Range0.156 ng/ml - 10 ng/ml
Sensitivity0.10 ng/ml
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
Size 196 tests
Size 25 × 96 tests
Size 310 × 96 tests
FormLyophilized
Tested ApplicationsELISA
Sample TypeSerum, plasma, cell culture supernatants and other biological fluids.
AvailabilityShipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
StorageShipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry IceNo
UniProt IDP01137, P04202, P17246
Gene ID7040, 21803, 59086
AliasCED,DPD1,IBDIMDE LAP,TGF-beta1,TGFB,TGFbeta
BackgroundElisa kits for TGFB1
StatusRUO
NoteValidity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

TGFB1 is a multifunctional cytokine that belongs to the transforming growth factor beta (TGF-β) family, which regulates cell proliferation, differentiation, apoptosis, and immune responses. TGFB1 is secreted as a latent complex that is activated in response to tissue injury, hypoxia, or cellular stress, enabling it to bind to its receptors and initiate downstream SMAD-dependent and non-SMAD signaling pathways. TGFB1 is a critical regulator of tissue homeostasis, embryonic development, and immune tolerance, where it suppresses inflammatory responses and promotes regulatory T cell (Treg) differentiation. In wound healing, TGFB1 induces extracellular matrix production and fibroblast activation, facilitating tissue repair and fibrosis. However, dysregulated TGFB1 signaling contributes to cancer progression by promoting epithelial-mesenchymal transition (EMT), immune evasion, and metastasis. It also drives fibrosis in chronic diseases, including pulmonary fibrosis and liver cirrhosis. Knockout studies reveal severe developmental defects, immune dysregulation, and impaired tissue repair, underscoring TGFB1's essential roles in cellular communication, immune modulation, and tissue remodeling.

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