Rat Transferrin (TF) Protein
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935106861
info@markelab.com
Precio
182€ (10 µg)
Protein TF
proveedor
Abbexareference
abx069404Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat Transferrin (TRF) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Transferrin (TF) is a glycoprotein that plays a central role in iron homeostasis by binding and transporting iron ions in the blood to various tissues, including the liver, bone marrow, and brain. It interacts with transferrin receptors (TFR1 and TFR2) on cell surfaces to mediate iron uptake through receptor-mediated endocytosis, ensuring iron availability for critical cellular processes such as hemoglobin synthesis, DNA replication, and energy metabolism. TF is produced primarily in the liver and is widely distributed in blood plasma. Dysregulation of transferrin leads to iron-related disorders, such as anemia, iron overload (hemochromatosis), and neurodegenerative diseases like Alzheimer’s, where altered iron metabolism contributes to oxidative stress and neuronal damage. Elevated transferrin levels are also associated with liver disease and systemic inflammation. Knockout studies demonstrate impaired iron transport, reduced erythropoiesis, and disrupted metabolic processes, emphasizing its essential role in systemic iron regulation, cellular function, and red blood cell production.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Transferrin (TRF)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 42.3 kDa Observed MW: 45 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Val360-Lys683 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
TF
dry ice
No
availability
Shipped within 5-7 working days.
alias
PRO1557,PRO2086,TFQTL1,HEL-S-71p
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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