Rat TNF-alpha Protein is a recombinant protein from Rat produced in E. coli. A DNA sequence encoding the mature form of rat TNFα (P16599) (Leu 80-Leu 235) was expressed and purified, with an initial Met at the N-terminus.
Tumor necrosis factor (TNF), also known as tumor necrosis factor alpha (TNF-α), is a multifaceted protein with characteristics of both an adipokine and a cytokine. It belongs to the TNF superfamily, a group of transmembrane proteins characterized by a homologous TNF domain. TNFα is produced and secreted by a variety of cells, including activated monocytes, macrophages, B cells, T cells, and fibroblasts. In its role as an adipokine, TNF contributes to insulin resistance and is linked to the development of type 2 diabetes in cases of obesity. As a cytokine, TNF plays a crucial role in cell signaling within the immune system. Has particular significance in sepsis. In animal models, the use of anti-TNFα treatments has been shown to reduce mortality during sepsis. Furthermore, in septic patients, the levels of TNFα in the bloodstream have been found to correlate with mortality rates. TNF is also known by several aliases, including TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, TNLG1F, and Tumor necrosis factor alpha.
Proteins and Peptides
Rat
E. coli
Tumor Necrosis Factor (TNF)
E. coli
SDS-PAGE
20 µg
Recombinant
> 93% (SDS-PAGE)
Lyophilized from sterile PBS, pH 7.4.
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
TNF
No
Shipped within 5-15 working days.
TNF,DIF,TNF-alpha,TNFA,TNFSF2,Tumour necrosis factor,TNF-α,TNLG1F,Tumor necrosis factor alpha, Cachectin
This product is for research use only. <p></p> Not for human consumption, cosmetic, therapeutic or diagnostic use.
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