Rat Tissue Factor Pathway Inhibitor (TFPI) Protein

Este producto es parte de TFPI - Tissue factor pathway inhibitor
Rat Tissue Factor Pathway Inhibitor (TFPI) Protein

Pida mas información

935106861

info@markelab.com

Precio

182€ (10 µg)

Protein TFPI

proveedor

Abbexa

reference

abx069319

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Tissue Factor Pathway Inhibitor (TFPI) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).


Background

Tissue Factor Pathway Inhibitor (TFPI) is a crucial regulator of the extrinsic coagulation cascade, primarily inhibiting the tissue factor (TF)-factor VIIa complex and factor Xa to maintain hemostasis and prevent excessive thrombosis. It is a Kunitz-type serine protease inhibitor, produced mainly by endothelial cells, and circulates bound to lipoproteins or as a free plasma protein. TFPI acts as a feedback inhibitor that ensures balanced thrombin generation, thereby reducing the risk of pathological clot formation. Dysregulation or deficiency in TFPI has been linked to thrombotic disorders and cardiovascular diseases. Beyond its anticoagulant role, TFPI exhibits anti-inflammatory properties, reducing vascular inflammation and protecting against atherosclerosis. It is also involved in angiogenesis and endothelial cell function, making it significant in vascular biology.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Tissue Factor Pathway Inhibitor (TFPI)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 32.7 kDa Observed MW (SDS-PAGE): 36 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu29-His302 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TFPI


dry ice

No


availability

Shipped within 5-7 working days.


alias

EPI, LACI, TFI, TFPI1,Extrinsic pathway inhibitor,EPI


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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