Rat Tissue Factor Pathway Inhibitor (TFPI) Protein
182€ (10 µg)
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Name
Rat Tissue Factor Pathway Inhibitor (TFPI) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx069319
Tested Applications
WB, SDS-PAGE
Description
Rat Tissue Factor Pathway Inhibitor (TFPI) is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Tissue Factor Pathway Inhibitor (TFPI) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Leu29-His302 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 32.7 kDa Observed MW (SDS-PAGE): 36 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q02445 |
| Alias | EPI, LACI, TFI, TFPI1,Extrinsic pathway inhibitor,EPI |
| Background | Protein TFPI |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Tissue Factor Pathway Inhibitor (TFPI) is a crucial regulator of the extrinsic coagulation cascade, primarily inhibiting the tissue factor (TF)-factor VIIa complex and factor Xa to maintain hemostasis and prevent excessive thrombosis. It is a Kunitz-type serine protease inhibitor, produced mainly by endothelial cells, and circulates bound to lipoproteins or as a free plasma protein. TFPI acts as a feedback inhibitor that ensures balanced thrombin generation, thereby reducing the risk of pathological clot formation. Dysregulation or deficiency in TFPI has been linked to thrombotic disorders and cardiovascular diseases. Beyond its anticoagulant role, TFPI exhibits anti-inflammatory properties, reducing vascular inflammation and protecting against atherosclerosis. It is also involved in angiogenesis and endothelial cell function, making it significant in vascular biology.
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