Rat Thyroid Hormone Receptor Alpha (THRa) Protein
208€ (10 µg)
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935106861
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name
Rat Thyroid Hormone Receptor Alpha (THRa) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx655237
tested applications
WB, SDS-PAGE
Description
Rat Thyroid Hormone Receptor Alpha (THRa) Protein is a Recombinant Rat protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Thyroid Hormone Receptor Alpha (THRa) |
| Host | E. coli |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 58.8 kDa Observed MW: 59 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Pro492 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | AR7,EAR7,ERBA,ERBA1,NR1A1,THRA1,THRA2,c-erbA,ERB-T-1,Tralpha,THRalpha,TRalpha1,TRalpha2,c-ERBA-1,THRalpha1,THRalpha2,Nuclear receptor subfamily 1 group A member 1,V-erbA-related protein 7 |
| Background | Protein THRA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Thyroid hormone receptor alpha (THRA) is a nuclear receptor that mediates the effects of thyroid hormones (T3 and T4) by regulating gene expression THRA exists in multiple isoforms, which are generated through alternative splicing and have tissue-specific functions The receptor plays a crucial role in the development, growth, and metabolism of various tissues, including the brain, heart, and muscles THRA regulates cellular processes such as metabolism, thermogenesis, and lipid metabolism by influencing the transcription of target genes involved in these pathways The receptor also has a vital role in the development of the nervous system, particularly during fetal and postnatal development Mutations in THRA can lead to various thyroid-related disorders, including resistance to thyroid hormone (RTH), where tissues become less responsive to thyroid hormones, resulting in elevated thyroid hormone levels and metabolic disturbances Additionally, THRA dysregulation has been implicated in certain cancers, where altered thyroid hormone signaling can contribute to tumor growth and progression
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