Rat Tachykinin Receptor 2 (TACR2) Protein

Este producto es parte de TACR - Tachykinin Receptor
Rat Tachykinin Receptor 2 (TACR2) Protein

Pida mas información

935106861

info@markelab.com

Precio

247€ (10 µg)

Protein TACR2

proveedor

Abbexa

reference

abx167773

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Tachykinin Receptor 2 Protein is a recombinant Rat protein expressed in E. coli.


Background

TACR2, also known as NK2R, is another member of the tachykinin receptor family, activated by neurokinin B (NKB) and substance P. Like TACR1, TACR2 primarily couples to Gq proteins, which activate phospholipase C (PLC), generating inositol triphosphate (IP3) and increasing intracellular calcium levels. TACR2 is widely expressed in the smooth muscle, particularly in the respiratory and gastrointestinal systems, where it regulates smooth muscle contraction. In the CNS, TACR2 plays a key role in regulating neurogenic inflammation and modulating pain, as well as contributing to the regulation of reproductive function. Dysregulation of TACR2 signaling has been linked to conditions such as asthma, chronic pain syndromes, and reproductive disorders. Selective TACR2 antagonists are being developed to treat asthma, IBS, and other conditions where neurokinin B-mediated effects contribute to disease pathology.

Características del producto

category

Proteins and Peptides


origin

Rat


host

E. coli


immunogen target

Tachykinin Receptor 2 (TACR2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 25.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Val200 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

TACR2


dry ice

No


availability

Shipped within 5-7 working days.


alias

TACR2,Neurokinin B receptor,NKNAR,SKR,TAC2R,neurokinin A receptor,NK-2 receptor,P-E receptor,Substance K receptor,NK2R


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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