Rat T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A) Protein
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935106861
info@markelab.com
Precio
260€ (10 µg)
Protein CD8A
proveedor
Abbexareference
abx065942Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Cluster Of Differentiation 8a (CD8a) is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
The CD8A gene encodes the alpha subunit of the CD8 glycoprotein, a key co-receptor expressed on the surface of cytotoxic T lymphocytes (CD8+ T cells). CD8A typically forms a heterodimer with CD8B or a homodimer (CD8αα). This protein plays a central role in T-cell activation and immune surveillance by interacting with MHC class I molecules on antigen-presenting cells. The interaction stabilizes the binding of the T-cell receptor (TCR) to antigenic peptides presented by MHC class I, facilitating signal transduction and T-cell-mediated cytotoxic responses. CD8A expression is essential for the development and maturation of CD8+ T cells in the thymus. It also participates in the immune response against viral infections, tumors, and intracellular pathogens. Mutations or dysregulation of CD8A can impair T-cell function and immune homeostasis.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
T-Cell Surface Glycoprotein CD8 Alpha Chain (CD8A)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 24.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly26-Val236 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
CD8A
dry ice
No
availability
Shipped within 5-7 working days.
alias
CD8,p32,Leu2,IMD116,CD8alpha,MAL,T-lymphocyte differentiation antigen T8/Leu-2,T-cell surface glycoprotein CD8 alpha chain
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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