Rat Suppressors Of Cytokine Signaling 2 (SOCS2) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein SOCS2
proveedor
Abbexareference
abx650715Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat SOCS2 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
SOCS2 is a member of the SOCS family of negative regulators that controls cytokine signaling through the JAK/STAT pathway by binding to phosphorylated cytokine receptors and targeting them for proteasomal degradation. SOCS2 primarily regulates growth hormone (GH), insulin-like growth factor 1 (IGF-1), and IL-6 signaling, modulating processes such as cell growth, differentiation, and metabolism. It is expressed in a variety of tissues, including the liver, skeletal muscle, and immune cells, where it balances cytokine-mediated cellular responses and prevents excessive signaling. SOCS2 plays a role in regulating growth and metabolism, as its deletion results in gigantism and increased sensitivity to growth hormone signaling. Dysregulation of SOCS2 has been linked to inflammatory diseases, insulin resistance, and cancer, where altered cytokine regulation promotes abnormal cell growth and survival. Knockout studies reveal excessive growth, immune cell hyperactivation, and increased susceptibility to inflammatory disorders, highlighting its role in maintaining cytokine signaling and growth homeostasis.
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Suppressors Of Cytokine Signaling 2 (SOCS2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 26.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Val198 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SOCS2
dry ice
No
availability
Shipped within 5-7 working days.
alias
CIS2,SSI2,Cish2,SSI-2,SOCS-2,STATI2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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