Rat Suppressors Of Cytokine Signaling 2 (SOCS2) ELISA Kit
689€ (96 tests)
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name
Rat Suppressors Of Cytokine Signaling 2 (SOCS2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx156103
tested applications
ELISA
Description
Rat Suppressors Of Cytokine Signaling 2 (SOCS2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Suppressors Of Cytokine Signaling 2 (SOCS2) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Suppressors Of Cytokine Signaling 2 (SOCS2)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Suppressors Of Cytokine Signaling 2 (SOCS2) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.13 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | CIS2,SSI2,Cish2,SSI-2,SOCS-2,STATI2 |
| Background | Elisa kits for SOCS2 |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SOCS2 is a member of the SOCS family of negative regulators that controls cytokine signaling through the JAK/STAT pathway by binding to phosphorylated cytokine receptors and targeting them for proteasomal degradation. SOCS2 primarily regulates growth hormone (GH), insulin-like growth factor 1 (IGF-1), and IL-6 signaling, modulating processes such as cell growth, differentiation, and metabolism. It is expressed in a variety of tissues, including the liver, skeletal muscle, and immune cells, where it balances cytokine-mediated cellular responses and prevents excessive signaling. SOCS2 plays a role in regulating growth and metabolism, as its deletion results in gigantism and increased sensitivity to growth hormone signaling. Dysregulation of SOCS2 has been linked to inflammatory diseases, insulin resistance, and cancer, where altered cytokine regulation promotes abnormal cell growth and survival. Knockout studies reveal excessive growth, immune cell hyperactivation, and increased susceptibility to inflammatory disorders, highlighting its role in maintaining cytokine signaling and growth homeostasis.
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