Rat Substance-P receptor (TACR1) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for TACR1
proveedor
Abbexareference
abx512806Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Substance-P receptor (TACR1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Substance-P receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
TACR1 is a G protein-coupled receptor (GPCR) that is activated by neurokinin A (NKA) and substance P, which are neuropeptides from the tachykinin family. TACR1 primarily couples to Gq proteins, which activate phospholipase C (PLC), leading to the production of inositol triphosphate (IP3) and the release of intracellular calcium. This results in smooth muscle contraction, vasodilation, and increased cell signaling. TACR1 is expressed in various tissues, including the central nervous system (CNS), gastrointestinal tract, and vasculature. In the CNS, TACR1 regulates pain perception, mood, and anxiety, while in the gastrointestinal system, it is involved in regulating motility and inflammation. Dysregulation of TACR1 signaling has been implicated in pain disorders, such as chronic inflammatory pain, and conditions like asthma and irritable bowel syndrome (IBS). Targeting TACR1 with antagonists is being explored as a potential therapy for pain management and other inflammatory diseases.
Características del producto
category
ELISA Kits
immunogen target
Substance-P receptor (TACR1)
reactivity
Rat
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.176 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
TACR1,SPR,Substance P receptor,NK1R,TAC1R,neurokinin receptor 1,NK1 receptor,NKIR
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
TACR1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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