Rat Sphingosine 1-phosphate receptor 5 (S1PR5) ELISA Kit

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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for S1PR5
proveedor
Abbexareference
abx256257Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Sphingosine 1-phosphate receptor 5 (S1PR5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Sphingosine 1-phosphate receptor 5 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
S1PR5 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), predominantly expressed in oligodendrocytes, natural killer (NK) cells, and endothelial cells. S1PR5 couples to Gi and G12/13 proteins, regulating pathways involved in cell migration, proliferation, and survival. In the central nervous system, S1PR5 plays a critical role in oligodendrocyte differentiation and myelination, contributing to neuronal protection and repair. It also regulates NK cell trafficking and activity, enhancing immune surveillance and anti-tumor responses. Dysregulation of S1PR5 signaling is implicated in neurodegenerative diseases, such as multiple sclerosis, where impaired myelination contributes to disease pathology. In cancer, S1PR5 expression is linked to immune evasion and tumor progression, particularly through modulation of NK cell function. S1PR5 agonists are being developed as therapies for multiple sclerosis to promote remyelination and reduce neuroinflammation, while its role in immune cell regulation makes it a promising target for cancer immunotherapy and inflammatory diseases.
Características del producto
category
ELISA Kits
immunogen target
Sphingosine 1-phosphate receptor 5 (S1PR5)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.091 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
S1PR5,EDG8,Edg-8,S1P5,SPPR-1,SPPR-2,endothelial differentiation G protein-coupled receptor 8,nerve growth factor-regulated G-protein-coupled receptor 1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
S1PR5
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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