Rat Sphingosine 1-phosphate receptor 2 (S1PR2) ELISA Kit

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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for S1PR2
proveedor
Abbexareference
abx512606Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat Sphingosine 1-phosphate receptor 2 (S1PR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat Sphingosine 1-phosphate receptor 2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
S1PR2 is a G protein-coupled receptor for sphingosine-1-phosphate (S1P), a bioactive lipid that regulates cell migration, proliferation, and vascular integrity. S1PR2 is expressed in endothelial cells, smooth muscle cells, and immune cells, where it couples primarily to G12/13 and Gq proteins. Its activation triggers downstream pathways, including Rho/ROCK and phospholipase C (PLC), leading to actin cytoskeletal reorganization and calcium signaling. S1PR2 plays critical roles in maintaining vascular tone, regulating endothelial barrier integrity, and inhibiting cell migration. It also contributes to immune cell retention in tissues, modulating inflammation and immune responses. Dysregulation of S1PR2 has been linked to inflammatory diseases, cardiovascular dysfunction, and neurodegeneration. In cancer, S1PR2 can act as a tumor suppressor by inhibiting migration and metastasis; however, in some contexts, it promotes inflammation and tumor progression. Targeting S1PR2 is under investigation for therapeutic applications in inflammation, vascular diseases, and cancer.
Características del producto
category
ELISA Kits
immunogen target
Sphingosine 1-phosphate receptor 2 (S1PR2)
reactivity
Rat
test range
0.625 ng/ml - 40 ng/ml
sensitivity
< 0.312 ng/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
S1PR2,AGR16,DFNB68,EDG-5,EDG5,Gpcr13,H218,LPB2,S1P2,endothelial differentiation G protein-coupled receptor 5,G protein-coupled receptor 13,GPCR18 ,S1P receptor 2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
S1PR2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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