Rat Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein
234€ (10 µg)
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Name
Rat Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx650696
Tested Applications
WB, SDS-PAGE
Description
Rat SAT1 Protein is a recombinant Rat protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Glu171 Tag: N-terminal His tag |
| Origin | Rat |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 23.7 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q6P9U6 |
| Alias | DC21,KFSD,KFSDX,SAT,SSAT,SSAT-1,Diamine acetyltransferase 1 |
| Background | Protein SAT1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Background
Spermidine/Spermine N1 Acetyltransferase 1 (SAT1) is a key enzyme involved in polyamine catabolism, catalyzing the acetylation of spermidine and spermine to produce acetylated derivatives that can be further metabolized or exported from the cell SAT1 regulates cellular polyamine levels, which are critical for processes such as DNA replication, transcription, translation, and cell growth Its activity is tightly controlled to maintain polyamine homeostasis, as imbalances can lead to cell death or uncontrolled proliferation Dysregulation of SAT1 has been associated with various conditions, including cancer, where altered polyamine metabolism supports tumor growth and survival SAT1 is also implicated in neurodegenerative disorders and oxidative stress responses, as polyamine metabolism influences reactive oxygen species (ROS) production and cellular damage Additionally, mutations or overexpression of SAT1 are linked to X-linked disorders such as Snyder-Robinson syndrome, characterized by intellectual disabilities and skeletal abnormalities SAT1 plays an emerging role as a potential therapeutic target for modulating polyamine metabolism in cancer and neurological diseases
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