Rat Spermidine/Spermine N1-Acetyltransferase 1 (SAT1) Protein

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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein SAT1
proveedor
Abbexareference
abx650696Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Rat SAT1 Protein is a recombinant Rat protein produced in a Prokaryotic expression system (E. coli).
Background
Spermidine/Spermine N1 Acetyltransferase 1 (SAT1) is a key enzyme involved in polyamine catabolism, catalyzing the acetylation of spermidine and spermine to produce acetylated derivatives that can be further metabolized or exported from the cell SAT1 regulates cellular polyamine levels, which are critical for processes such as DNA replication, transcription, translation, and cell growth Its activity is tightly controlled to maintain polyamine homeostasis, as imbalances can lead to cell death or uncontrolled proliferation Dysregulation of SAT1 has been associated with various conditions, including cancer, where altered polyamine metabolism supports tumor growth and survival SAT1 is also implicated in neurodegenerative disorders and oxidative stress responses, as polyamine metabolism influences reactive oxygen species (ROS) production and cellular damage Additionally, mutations or overexpression of SAT1 are linked to X-linked disorders such as Snyder-Robinson syndrome, characterized by intellectual disabilities and skeletal abnormalities SAT1 plays an emerging role as a potential therapeutic target for modulating polyamine metabolism in cancer and neurological diseases
Características del producto
category
Proteins and Peptides
origin
Rat
host
E. coli
immunogen target
Spermidine/Spermine N1-Acetyltransferase 1 (SAT1)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 23.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Glu171 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
SAT1
dry ice
No
availability
Shipped within 5-7 working days.
alias
DC21,KFSD,KFSDX,SAT,SSAT,SSAT-1,Diamine acetyltransferase 1
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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