Rat SH2 Domain Containing 4A (SH2D4A) ELISA Kit
715€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Rat SH2 Domain Containing 4A (SH2D4A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx545638
tested applications
ELISA
Description
Rat SH2 Domain Containing 4A (SH2D4A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH2 domain-containing protein 4A concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | SH2 Domain Containing 4A (SH2D4A) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q6AYC8 |
| Alias | PPP1R38, SH2A |
| Background | Elisa kits for SH2D4A |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
SH2D4A is an SH2 domain-containing protein that functions as a negative regulator of signaling pathways activated by receptor tyrosine kinases and cytokine receptors. It interacts with signaling molecules like STAT proteins and phosphatases to inhibit downstream pathways such as JAK/STAT and MAPK, modulating processes like cell proliferation, differentiation, and immune responses. SH2D4A is predominantly expressed in immune cells and tissues involved in hematopoiesis, where it plays a role in regulating cytokine signaling and immune homeostasis. It functions as a tumor suppressor in certain contexts, inhibiting excessive proliferation and survival signaling. Dysregulation or loss of SH2D4A has been linked to cancer progression and immune disorders due to uncontrolled activation of cytokine signaling. Knockout studies reveal hyperactive immune responses, abnormal proliferation, and defects in cytokine regulation, emphasizing its role as a critical negative regulator of cellular signaling pathways.
Related Products
SH2D4A antibody
Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function.
Ver Producto
Sh2 Domain Containing 4A (SH2D4A) Antibody
Sh2 Domain Containing 4A Antibody is a Rabbit Polyclonal antibody against Sh2 Domain Containing 4A.
Ver Producto
SH2 Domain Containing 4A (SH2D4A) Antibody
SH2D4A Antibody is a Rabbit Polyclonal against SH2D4A.
Ver Producto