Rat SH2 Domain Containing 4A (SH2D4A) ELISA Kit
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935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for SH2D4A
proveedor
Abbexareference
abx545638Tested Applications
ELISAreactivity
Ratstatus
RUOclonality
Descripción
Rat SH2 Domain Containing 4A (SH2D4A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat SH2 domain-containing protein 4A concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
SH2D4A is an SH2 domain-containing protein that functions as a negative regulator of signaling pathways activated by receptor tyrosine kinases and cytokine receptors. It interacts with signaling molecules like STAT proteins and phosphatases to inhibit downstream pathways such as JAK/STAT and MAPK, modulating processes like cell proliferation, differentiation, and immune responses. SH2D4A is predominantly expressed in immune cells and tissues involved in hematopoiesis, where it plays a role in regulating cytokine signaling and immune homeostasis. It functions as a tumor suppressor in certain contexts, inhibiting excessive proliferation and survival signaling. Dysregulation or loss of SH2D4A has been linked to cancer progression and immune disorders due to uncontrolled activation of cytokine signaling. Knockout studies reveal hyperactive immune responses, abnormal proliferation, and defects in cytokine regulation, emphasizing its role as a critical negative regulator of cellular signaling pathways.
Características del producto
category
ELISA Kits
immunogen target
SH2 Domain Containing 4A (SH2D4A)
reactivity
Rat
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
PPP1R38, SH2A
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SH2D4A
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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