Rat RAR Related Orphan Receptor Gamma (RORg) Protein

Este producto es parte de RAR related orphan receptor
Rat RAR Related Orphan Receptor Gamma (RORg) Protein
221€ (10 µg)

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Name
Rat RAR Related Orphan Receptor Gamma (RORg) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx654904
Tested Applications
WB, SDS-PAGE

Description

Rat RAR Related Orphan Receptor Gamma (RORg) Protein is a recombinant Rat protein expressed in E. coli.

Documentos del producto

Instrucciones
Data sheet
Descargar

Especificaciones del producto

Category
Proteins and Peptides
Immunogen Target
RAR Related Orphan Receptor Gamma (RORg)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Origin
Rat
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
Alias
TOR,RORG,RZRG,IMD42,NR1F, RZR-GAMMA,Nuclear receptor ROR-gamma,RAR-related orphan receptor C,Nuclear receptor subfamily 1 group F member 3
Background
Protein RORC
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Background

RAR related orphan receptor C (RORC), also known as RORγ, is a nuclear receptor that plays a crucial role in regulating immune responses, particularly in the differentiation of Th17 cells, which are a subset of helper T cells involved in autoimmune diseases RORC is essential for the regulation of inflammatory processes and the production of pro-inflammatory cytokines, making it a key player in the pathogenesis of conditions like rheumatoid arthritis, psoriasis, and multiple sclerosis RORC also influences the development of the thymus and other immune organs, playing a role in maintaining immune homeostasis It is involved in the regulation of metabolic processes and the response to oxidative stress and environmental factors Dysregulation of RORC expression is linked to autoimmune diseases, chronic inflammation, and cancer, where altered immune regulation contributes to disease progression Targeting RORC with specific inhibitors has been explored as a therapeutic strategy to manage autoimmune diseases and inflammatory conditions, highlighting its potential as a drug target in immune-related therapies

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