Rat PYD And CARD Domain Containing Protein (PYCARD) ELISA Kit
767€ (96 tests)
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935106861
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name
Rat PYD And CARD Domain Containing Protein (PYCARD) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx585174
tested applications
ELISA
Description
Rat PYD And CARD Domain Containing Protein (PYCARD) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Rat PYD And CARD Domain Containing Protein (PYCARD) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | PYD And CARD Domain Containing Protein (PYCARD) |
| Reactivity | Rat |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.07 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ASC, CARD5, TMS, TMS-1, TMS1,Apoptosis-associated speck-like protein containing a CARD |
| Background | Elisa kits for PYCARD |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
PYD and CARD domain containing (PYCARD), also known as ASC (apoptosis-associated speck-like protein containing a CARD), is a bipartite adaptor protein involved in innate immunity and inflammation PYCARD contains both a PYRIN domain (PYD) and a caspase recruitment domain (CARD), which facilitate its interaction with inflammasome components such as NLRP3 and caspase-1 PYCARD is essential for inflammasome assembly, leading to the activation of caspase-1, which processes pro-inflammatory cytokines IL-1β and IL-18 and induces pyroptosis, a form of inflammatory cell death Dysregulation of PYCARD has been implicated in inflammatory diseases such as gout, where it activates inflammasomes in response to uric acid crystals, and in autoimmune disorders including lupus PYCARD is also involved in apoptosis, interacting with pro-apoptotic factors to regulate programmed cell death Its overactivation or suppression has been associated with cancer, neuroinflammation, and metabolic diseases, highlighting its critical role in balancing inflammation and cell survival
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